Janice Y Chou Selected Research

Liver Cell Adenoma (Hepatocellular Adenoma)

1/2019	Gene therapy prevents hepatic tumor initiation in murine glycogen storage disease type Ia at the tumor-developing stage.
5/2018	Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia.
1/2018	Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia.
11/2017	Liver-directed gene therapy for murine glycogen storage disease type Ib.
9/2017	Recent development and gene therapy for glycogen storage disease type Ia.
1/2017	Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy.
1/2017	Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-α activity restored are at risk of developing hepatic tumors.
6/2015	Minimal hepatic glucose-6-phosphatase-α activity required to sustain survival and prevent hepatocellular adenoma formation in murine glycogen storage disease type Ia.
9/2014	Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-α deficiency.
11/2012	Prevention of hepatocellular adenoma and correction of metabolic abnormalities in murine glycogen storage disease type Ia by gene therapy.

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Janice Y Chou Research Topics

Disease

20	Hepatorenal form of glycogen storage disease 01/2021 - 11/2004
14	Glycogen Storage Disease (Glycogenosis) 11/2018 - 04/2007
11	Liver Cell Adenoma (Hepatocellular Adenoma) 01/2019 - 11/2009
10	Neutropenia 11/2018 - 03/2007
9	Glycogen Storage Disease IB 11/2018 - 04/2007
6	Neoplasms (Cancer) 01/2020 - 01/2017
5	Hypoglycemia (Reactive Hypoglycemia) 01/2021 - 07/2008
5	Carcinoma (Carcinomatosis) 01/2019 - 01/2017
5	Hepatomegaly 05/2017 - 07/2008
3	Insulin Resistance 11/2017 - 09/2015
3	Obesity 11/2017 - 09/2015
3	Hyperuricemia 11/2013 - 07/2008
3	Hyperlipidemias (Hyperlipidemia) 11/2013 - 07/2008
2	Seizures (Absence Seizure) 01/2021 - 06/2015
2	Carcinogenesis 01/2020 - 01/2017
2	Autosomal Recessive 3 Severe Congenital Neutropenia 05/2015 - 10/2010
1	Immune System Diseases (Immune Disorders) 11/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 05/2018
1	Hepatocellular Carcinoma (Hepatoma) 09/2017
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Autosomal Recessive 4 Severe Congenital Neutropenia 05/2015
1	Hypoxia (Hypoxemia) 05/2014
1	Glycogen Storage Disease Type I 12/2010
1	WHIM syndrome 10/2010
1	Lactic Acidosis 07/2010
1	Inborn Genetic Diseases (Disease, Hereditary) 07/2010
1	Fibrosis (Cirrhosis) 04/2010
1	Necrosis 03/2008
1	Wounds and Injuries (Trauma) 03/2008
1	Bacterial Infections (Bacterial Infection) 03/2007
1	Peritonitis 03/2007
1	Hypercholesterolemia 11/2006
1	Hypertriglyceridemia 11/2006
1	Atherosclerosis 11/2006

Drug/Important Bio-Agent (IBA)

30	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 04/2007
13	Glucose-6-PhosphateIBA 11/2018 - 06/2008
6	EnzymesIBA 01/2020 - 04/2007
4	Sirtuin 1IBA 01/2020 - 01/2017
3	GlycogenIBA 05/2017 - 11/2009
3	AntiportersIBA 01/2009 - 07/2008
3	Phosphates (Orthophosphate)IBA 01/2009 - 07/2008
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021 - 06/2015
2	Pyruvate KinaseIBA 01/2020 - 01/2018
2	Protein Isoforms (Isoforms)IBA 01/2020 - 01/2018
2	Blood Glucose (Blood Sugar)IBA 05/2015 - 04/2007
2	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 05/2015 - 11/2004
2	Caspase 3 (Caspase-3)IBA 04/2011 - 06/2008
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 04/2011 - 10/2010
2	AntioxidantsIBA 04/2010 - 11/2006
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2020
1	TOR Serine-Threonine KinasesIBA 01/2020
1	Codon (Codons)IBA 01/2020
1	SirtuinsIBA 05/2018
1	HexokinaseIBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 11/2017
1	CarbohydratesIBA 11/2017
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	fibroblast growth factor 21IBA 01/2017
1	Cadherins (E-Cadherin)IBA 01/2017
1	CateninsIBA 01/2017
1	Peroxisome ProliferatorsIBA 05/2014
1	phosphatidylinositol 3,4,5-triphosphateIBA 04/2011
1	Chemokine ReceptorsIBA 10/2010
1	plerixafor FDA Link 10/2010
1	NitrogenIBA 04/2010
1	tempolIBA 04/2010
1	Pharmaceutical PreparationsIBA 04/2010
1	Urea (Carbamide)FDA LinkGeneric 04/2010
1	AngiotensinsIBA 04/2010
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 04/2010
1	Liver GlycogenIBA 11/2009
1	Annexin A5IBA 06/2008
1	ChemokinesIBA 03/2008
1	CytokinesIBA 08/2007
1	glucose-regulated proteinsIBA 03/2007
1	CalciumIBA 03/2007
1	CholesterolIBA 11/2006
1	Scavenger Receptors (Scavenger Receptor)IBA 11/2006
1	HDL LipoproteinsIBA 11/2006
1	LipidsIBA 11/2006
1	VLDL LipoproteinsIBA 11/2006

Therapy/Procedure

5	Therapeutics 09/2017 - 11/2009